Yohimbine and PTSD

I was at a seminar a few weeks ago and someone sitting next to me was reading a 1999 article in Biological Psychiatry titled "Yohimbine Use in a Natural Setting: Effects on Posttraumatic Stress Disorder". He saw me reading over his shoulder and gave me an extra copy he just happened to have. It consists of four case reports and a brief discussion. Here's part of one report:

Six years after Vietnam, RC again tried yohimbine expecting to recreate his earlier pleasant experience with the drug. Four friends, one a combat veteran, joined him. RC's three non-veteran friends reported an energized and sensual feeling. RC and his combat veteran friend both experienced a panic attack and flashback. "I felt like I was going crazy. I was sweating and shaking and my heart seemed like it was pounding outside of my chest. It seemed like I was losing my mind. At first I thought we had been poisoned, but I could see that three of my friends were fine. The whole thing was terrifying and seemed like it lasted for a long time. I kept thinking that my combat buddy was wounded. I kept thinking that I was a medic and that I had to save him. He was having a terrible time too."

It's fairly widely accepted at this point that the noradrenergic system plays a crucial role in PTSD. Some recent research (which I'm too lazy to look up right now) suggested that administering adrenergic antagonists immediately after traumatic experiences could prevent the development of PTSD. Yohimbine is, perhaps among other things, a strong agonist and so it makes sense that it could have this effect.