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Amping the brain's amphetamine DAT drive

You know that rush you get after snorting a line of Cocaine? That's due to a fine mist of dopamine molecules purging from their synaptic terminals all at once; a little trick that amphetamines are famous for. Now what happens if you could deliver more dopamine per rush? That's exactly what mad scientists are trying to do with DAT enhancers, drugs that help manufacture the transport proteins needed to handle the surplus dopamine output seen in amphetamine stimulation.

To investigate the consequence of high DAT levels, the researchers developed transgenic mice with three-fold higher levels of DAT compared with unmodified animals. The authors discovered that [amphetamine] was more powerful in animals with more DAT. The dopamine-enhanced animals were more sensitive to the effects of amphetamines, becoming hyperactive and more rewarded by the drug, according to the authors.

Yes, making recreational drug use more rewarding is exactly where I want my tax money going. Extrapolating this out to absurd levels, imagine cutting your speed with industrial DAT enhancers imported from China, and then being able to go three days without sleep on a single hit of meth. What would you call that? Turbo-meth? No, that's already taken. Stupid media.

Posted By jamesk at 2008-04-03 11:39:16 permalink | comments
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dan. : 2009-12-24 14:27:49
we want dat pills ..ok
zupakomputer. : 2008-04-09 14:06:52
Why don't any of those online 'pharmacies' sell dental cocaine anyway? They're all rubbish; best they do is valium. Do you realise how many great pharms they could be selling.
Adam L. : 2008-04-04 16:53:38
great now crack itself is on crack.

I just hope no form of DAT (whether clean or cheap) is cheap enough to cut anythnig with!
Then again nothing you get from the pharmacy is more expensive than cocaine already is, unless you have cancer. Then they can make you pay anything.

DM. : 2008-04-03 20:54:35
That is a righteous graphic, where'd you find it?
jamesk : 2008-04-03 18:21:52
Oops, my bad. You can see right in the picture the happy reuptake gremlins love the DAT. Not axonal transport, reuptake transport.
DM. : 2008-04-03 13:24:36
AFAIK DA is synthesized in the terminal, not the cell body, and then packaged into vesicles. DAT refers to the reuptake transporter, which is made to act in reverse by amphetamine, which explains the more DAT -> more amphetamine buzz effects.

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