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The wonders of, uh, scopolamine

In case you missed it, Boing Boing recently came across a TV news piece about the evils of scopolamine. One of their readers summarized the piece:

This stuff is as close to pure evil as it gets, a tiny amount of the powder administered to the victim causes one of two effects, a) death, or b) complete loss of free will. Criminals are usually hoping for the latter, as it enables them to tell victims to empty their bank accounts, give away their car, perform sex acts, basically whatever the criminal dictates.

This is where Scopolamine has got its reputation as the "zombie drug", victims appear completely sober and rational, but they're really just automatons.

Xeni goes on to describe scopolamine's use treating motion sickness, and the comments thread that follows is pretty spirited. But nowhere do I see any mention of scopolamine's use as a smoking cessation agent. I heard about this from some friends on the east coast who were pretty enthusiastic about it, although it also sounded a little on the zany side. Here's one description of the treatment:

Atropine and scopolamine combination therapy: Some smoking cessation clinics offer a program using shots of the anticholinergic drugs atropine and scopolamine to help reduce nicotine withdrawal symptoms. These drugs are more commonly prescribed for other reasons, such as digestive system problems, motion sickness, or Parkinson’s disease.

The treatment usually involves shots given in the clinic on one day, followed by a few weeks of pills and wearing patches behind the ear. It may include other drugs to help with side effects as well.

Possible side effects of this treatment can include dizziness, constipation, dry mouth, an altered sense of taste and smell, problems urinating, and blurry vision. People who are pregnant or have a history of heart problems, glaucoma, or uncontrolled high blood pressure are not allowed to participate in these programs.

Some clinics claim high success rates, but there is no published scientific research to back up these claims. Both atropine and scopolamine are FDA approved for other uses, but they have not been formally studied or approved for help in quitting smoking. Before considering such a program, you may want to ask the clinic about long-term success rates (up to a year). Because these medicines are directed only at the physical aspect of quitting, you may also want to ask if the program includes counseling or other methods aimed at the psychological aspects of quitting.

Maybe some of you who have undertaken this program would care to chime in?

Posted By Scotto at 2007-10-01 09:05:50 permalink | comments
Tags: scopolamine
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InDallas. : 2011-05-26 17:31:06
Just got back from the Dr. with my girlfriend. She took the medication and is bed resting. She did act a little intoxicated. A little giggly, slurred speech but the biggist thing is the resltess leg. She really got irritated when we got home. Said her right leg ached so bad she couldn't take it. Took one Valium after leaving and then took a second one about an hour later. Now she is finally asleep and resting.
Aumdoc : 2007-10-02 07:30:19
I have experience administering atropine/scopolamine injections for nicotine addiction. I took the job at the clinic two days a month to make some additional income. I found out about the clinic because my dear friend, S, was successful quitting smoking through the clinic. I had watched S literally torment himself for 2 years trying to quit smoking. Every method he could try he did... patches, zyban, coldturkey... all without success. It wasn't really his trying to quit that got to me, it was more the self recrimination when he failed.

S has quite an interest in plants, especially those with a history of psychotropic human interaction. Among the many cactii on his back deck there are many tree datura's in pots with beautiful trumpet flowers. He loves those plants. To both him and I it seems no small coincidence that he ended up quitting using alkaloids found in these plants (and others as well, brugmansia & jimson weed come to mind). He was assisted by his plant allies.

Whenever one reads about "recreational (!?!)" use of these plants on erowid, the reports almost always end with uncontrolled bizarre behavior that usually calls the attention of authorities. Dosing from the plant source is very unpredictable and overdosing seems common with trouble that follows. These plants are used in indiginous shamanic settings as admixtures in ayahuasca or smoking mixtures. I think the indiginous shamans have a better handle on how to use them than the average American drug user.

I was so impressed by S's success that when I needed a few days extra work each month I contacted the clinic. Now S kids me about shooting 'Datura Darts'. In this therapy the individual is screened medically (history and physical, ekg, pulmonary function tests) to make sure they are a safe candidate for the therapy. They then receive injection therapy, with specific weight based doses of atropine and scopolamine, to provide anticholinergic effects on nicotine receptors. Once processed through the clinic (they watch video's and receive behavioral counseling) they continue scopolamine and atropine orally for 2 weeks.

We discuss that these are not new medications and have been and are used in many different ways in medicine.

Patients routinely have a 'big experience' with the shots.... meaning the feel something..... ("ooooooooooooo this must be powerful medicine if it makes me feel this way")... I can't help but feel this has something to do with the effectiveness of the method. I tell people what to expect from the shots...." you may feel dizzy or lightheaded and off balance; your pupils will dilate making lights bright and it difficult to focus (like coming out of the eye doctors); you will have a very dry mouth; it is most common for people to be sedated and fall asleep on the ride home; it is very common for people to describe feeling stoned, drunk or intoxicated. Some people like it and some don't. Often times people look drunk as they walk out of the clinic.

I have been doing this since march, 2 days a month, and am amazed at how many people stop smoking who have been unable to do so over a lifetime. I do not have this years numbers yet (success rates from the clinics follow up) but feel it will be more than 50%. People describe a loss of craving immediately. This is a clinic situation who will take anyone who pays and passes the medical screening. I don't think all these people are really ready to quit and I feel that is an important part of success. With establishment of more clear screening guidelines I think it would be even more effective.

The effects are very predictable using the weight based dosing schedule. I have not had any problems with psychotropic or other medical adverse reactions. Yes, some people have some 'unusual' experiencI as they describe to me, but nothing untoward. Older individuals (>60 y/o) also seem to tolerate the treatment.

I have spent six months connecting to the Datura's in my yard and spending time using plant material at very very low dose to try to further connect with the beneficial effects of Datura Darts. I always comment to patients that these are not new medicine's and in fact the plants these chemicals come from were used as medicine long before there were doctors.

Aumdoc

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