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Food might be addictive

As our culture continues its quest for the perfect anti-obesity pill, researchers are starting to uncover hints that - yes, you guessed it - food might actually be addictive.

Brain imaging soon may provide answers. At Brookhaven National Laboratory in New York, psychiatrist Nora D. Volkow and her colleagues map dopamine receptors on brain cells. This neurotransmitter plays a key role in addiction. Dopamine systems are disrupted by addictive drugs, from alcohol to methamphetamine, which hijack the control of volition and the quest for rewards.

It turns out that food also affects the brain's dopamine systems. When Dr. Volkow, who is also director of the National Institute on Drug Abuse, compared brain images of methamphetamine users with those of obese people, she found both groups had significantly fewer dopamine receptors than healthy people. Even more interesting: The higher the body mass index, the fewer the dopamine receptors.

Does this open any significant doors for treatment? Not necessarily, but every little bit helps in the sense that we can get even more research dollars applied once we get this properly and fully described as a medical abnormality at the root and not simply at the level of a set of unhealthy symptoms.

Posted By Scotto at 2007-09-21 00:48:00 permalink | comments
Tags: obesity
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the.thistle : 2007-09-22 15:54:46
Nice find.

The neuroscience of nutrition is a relatively new field. I suspect that once it really gets going, it will shed light on some unsolved problems of neuroscience generally, not least of all addiction.

My first response upon reading the above was, "Of course it would be addictive." Food-seeking behavior has to be governed by some mechanism, just like drug-seeking behavior. Now, I can't say I'm familiar with much of the literature in this area (all caveats invoked), but it seems to me that there's no reason to assume there would be two separate motivation centers for the two types of behaviors. In fact, we know that some addicted to drugs (depending on degree of the addiction and other factors) will actually forgo behaviors which would otherwise further their survival, suggesting that one mechanism is getting repurposed.

A second thought is that even if addiction could be localized in one of the dopamine systems, that does not mean that it is necessarily the result of a medical abnormality. The neurons might be functioning exactly as it was designed to by evolution and still be yielding the end product of "addiction." So far as I know, methamphetamine made its global debut less than 100 years ago (no known direct plant sources); the human nervous system didn't evolve with meth being a factor. Likewise, food addiction could be a result of particular distortions in the food environment (and lifestyle) from evolutionary conditions.

Problem is, drug neuroscience would have a hard time dealing with such an explanation, since it seems set on finding causative correlations between individual drugs, individual brain regions, and individual behaviors.

Third: the biggest hole in this article is this notion of "volition." "Dopamine systems are disrupted by addictive drugs, from alcohol to methamphetamine, which hijack the control of volition and the quest for rewards." Are any drug nerds at Dosenation aware of neuroscientific definitions of volition? Sounds like they're trying to sneak free will in by the back door.

pmp333 : 2007-09-22 07:49:16
Mucuna Pruriens and Deprenyl are both useful for re-balancing that neurotransmitter subsystem. I wouldn't recommend combining them carelessly, however.

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