Harvard's headache cure: LSD?

I agree with Rick on this point: " Rightly so, the psychedelic code of honor is absolutely against cooperation with the police by providing information against others for matters that should not even be crimes in the first place. John and others did so and violated this code of honor."

I happen to have served over 9 years for making LSD and other suchness as the result of a "common informer" or any other way you want to say a spineless turd without the courage to be responsible for their own actions and not lay it on someone else's table. Of course, I can have compassion for the weak AND I'll never trust them again with such matters. Hindsight is awesome.

The real issue remains, Leonard is still serving not one but TWO life sentences, as if one wouldn't deter others from following his footsteps and make a molecule most of us "entheogenista rebels" revere. I was lucky, I served less than a decade. Or said another way, I served about 1/4 of my life sentence to date.

As for EntheoCorp, what a fucking stab in the heart of so many who strive for an integrated entheogenic life. On that count too, to use the proper English, John is a cunt.

As for forgiveness, the guy who snitched on me, he's done killed himself. Like I said in my Halperngate II contribution, "I forgive him and indeed will always love him. Whilst I could not ever visualize myself in his position, I can empathize." Hardly an extreme attitude! At least I am alive. Leonard may never see the outside of the prison walls until he dies.

And that hurts!

Fiat lux!

Cx

Dr. Sewell says RE: BOL-148's origins: "...either way you slice it, it wasn't Halpern's idea."

Where does this leave the Entheogen Corp? As, according to their website, BOL-148 is the calling card of this organization... would it not be possible to prove that Entheogen Corp has no right to an exclusive patent for BOL-148?

As timing is everything (and from the perspective of a CH sufferer, the FDA's timing will be quite slow in approving the medicine)... would it perhaps be best to wait until BOL-148 exits the FDA gauntlet and is provided to CH sufferers before engaging in the legal dispute of Entheogen Corp's ownership of the medicine and the credit?

Where is Doblin's response to Sewell's testimony?

BTW-Jon Hanna quotes Ann Shulgin RE: The "DeeEeeAy"... where does this leave the skeptic to wander, when Sasha Shulgin's contribution to the DEA (as its most famous contracted employee chemist) cannot be exaggerated?

Perhaps there are connections to this tip of the iceberg aka... 'Halperngate' that illustrate a strange relationship that psychedelic 'celebrities' love/hate with the enforcers... perhaps layers of deception and ass-saving conceal this iceberg.

So glad to see John back in the headlines!

We are no longer accepting anonymous comments on this post. If you have something to say about this issue, it must be on the record as an actual person. Thank you. If you use a pseudonym or are not logged in as an identified user, your comment will be deleted.

I would say that Jon Hanna is correct, and that the idea was inspired by Frederigo Sicuteri's 1963 paper "Prophylactic Treatment of Migraine by Means of Lysergic Acid Derivatives". In it, Dr. Sicuteri gave LSD-25, BOL-148, and methysergide to 238 patients with a mixture of headache types--cluster, migraine, what sounds like tension headache, and "chronic intracranial inflammation" headache, whatever that is. He found that methysergide worked better than LSD, which worked better than BOL.

What he didn't do, however, was separate out the cluster headache group and ask how well LSD worked to terminate their cluster periods or extend their remission periods. He came very close to discovering LSD's therapeutic properties for cluster headache, fifty years ago, but just didn't ask the right questions. Given that, I naturally wondered if he might have missed the same therapeutic properties for BOL. Even though it is not hallucinogenic, we don't have any particular reason to suppose that LSD's effects on headache are mediated by 5-HT2A; it affects a lot of receptors. It seemed worth a try, anyway.

Technically speaking, then, the idea to give BOL to cluster headache patients was not mine but rather Dr. Sicuteri's; I simply asked a different question than he did. But either way you slice it, it wasn't Halpern's idea.

And as far as the actual clinical trial goes, the trial was run by Dr. Matthias Karst at Hannover Medical School, in Torsten Passie's lab. Dr. Passie did the "heavy lifting" of interfacing with the mind-numbing regulatory agencies involved and mentoring Dr. Karst, who is his junior, and Dr. Karst did the actual work of administering the drug, recording the results, and writing and publishing the final paper. What Dr. Halpern did isn't entirely clear. Did he fly out to Germany every time they recruited a new subject? It seems doubtful, since he is not licensed to practice medicine in Germany. I'm not sure what he is supposed to have done, or what work he can reasonably claim credit for.

In summary, Dr. Halpern neither had the original idea, nor did he do the work. He recognizes a good idea when he sees one, and is doing his best to cash in. Whether that's worth adulation and respect is up to individual readers. I certainly don't think so. If it ends up actually helping cluster headache patients, then I'll change my opinion, but until it has, it hasn't.

Rick Doblin states:

"When someone is accused of being an informant, that is understood to mean that the informant was working secretly to provide information that led to an arrest. John was not an informant."

Rick knows that John H. Halpern DID work secretly with the DEA following the Y2K silo bust, and that Halpern provided information to the DEA to aid them, in exchange for getting his own bacon out of the frying pan. Halpern was interviewed by the DEA at least nine times from December 4, 2000 through May 17, 2002. Did Halpern provide the lion's share of evidence used in the case to lock up, specifically, LSD producers William Leonard Pickard and Clyde Apperson? No, he did not; Rick is correct on that point.

Did Halpern state publicly in January of 2006 that he never provided testimony related to the silo case? Yes, he did. Is that true? No, it is a lie. Was Halpern's "cooperation limited entirely to matters relating to Leonard [Pickard]", as Rick states? Over a year AFTER Pickard and Apperson were found guilty (with Pickard then being sentenced to TWO life sentences), Halpern continued to work with the DEA by providing testimony in front of a Grand Jury in San Francisco on October 7, 2004. (This certainly seems to contradict Rick's statement that Halpern's "cooperation [was] limited entirely to matters relating to Leonard [Pickard]"; I mean, are we to believe that the DEA was trying to give Pickard a third life sentence, and they needed Johnny's help with that?) Then, on January 7th, 2008, federal agents arrested Halpern's childhood friend and purported money-laundering connection Stefan Wathne, whom Halpern was responsible for introducing to Pickard. These last two details were missing from my "Halperngate" article; in the first case, because I was unaware of it at the time the article was written, due to the indictment being sealed. (That means it was kept secret.) And in the second case, the arrest happened after the article was written. I wonder how many people know these two details. Perhaps someday enough will be known for a "Halperngate III" article.) Thankfully, Wathne had an excellent attorney, and the case did not go to trial--where Halpern would have very likely been called to testify.

I can see why some people might have a bone to pick against Rick Doblin's opinion that the word "informant" is not accurate in describing Halpern. However, the word "snitch" unquestionably fits.

What can not be argued is the fact that even eight years after the silo bust, the DEA had not given up on trying to put someone ELSE in prison. And to quote Ann Shulgin on the topic:

"You've probably heard sayings to the effect that you should not get a loan (or accept a favor) from the Mafia, because once that organization has helped you, they consider you their property, so to speak, and you'll never be free of them. The same can be said of the DeeEeeAy. Once you've rolled over (to use the current nasty phrase) for that organization, they own you, and they can demand continuing cooperation for an indefinite length of time." (March 14, 2006)

The "Taliban" mudslinging made within the Comments posted in response to DoseNation's reposting of "Harvard's headache cure: LSD?" is laughable; the fact that these remarks are anonymous is perhaps telling. Inspired by Rick having jumped into the fray here (I would have otherwise remained silent and ignored the attack on my character, Rick), I have no need or desire post pseudonymously. I have opinions, I state what I believe is true, I stand behind my words. I am hardly "paranoid".

There is some suggestion that the Halperngate article does not qualify as journalism. It is often the case that newspaper and magazine articles don't cite their source material. My article--which does cite its sources--is therefore more like something that would appear in a professional or academic journal than it is like mainstream news. Along with allowing for a variety of opinions to be expressed, I worked hard to make sure that the article was factual; if someone checks the sources cited and finds an error I have made (or repeated), if there is any published material that presents factual data in conflict with that which I have presented, I am eager to hear about it. "Those" who suggest in a general and non-evidenced way that the article is inaccurate might point out the supposed flaws, rather than throwing insults at me for writing it. As noted in my article, "Both Doblin and Halpern were given every opportunity to correct any errors of fact." The resulting article has exactly as much ACTUAL fact correction as each of them provided (and I was in communication with both of them).

"Shroomer" asks: "Have any of these Halpern-haters ever done a single thing to advance research that may lead to an important medicine?" Let me suggest that Dr. Andrew Sewell (an MD who is board-certified in both neurology and psychiatry, as well as serving on the Erowid Expert Network and the Scientific Program Committee of the American Neuropsychiatric Association, and a former colleague of Halpern), is likely someone who has no love for Halpern. And Sewell's work has contributed greatly to spreading the word about psychedelic treatments, both in medical journals and in the underground literature. Sewell is the person responsible for posting cluster headache questionnaires on the web that provided results related to the efficacy of psilocybin and LSD as treatments. For The Entheogen Review, Sewell wrote the comprehensive article "Unauthorized Research on Cluster Headache," which pointed out that the true roots of the discovery that psilocybin, ergine, and LSD can help cluster headache came from the underground--not from white-coats in labs. Real-world help may be available to those who suffer from cluster headaches RIGHT NOW, with no need to involve the pharmaceutical industry or snitches. See [link] (ergine can be obtained by extracting it from completely legal seeds; the chemical itself is only Schedule III--not Schedule I like most other psychedelics; if the seeds were processed just before consumption, the likelihood of any user arrests seems virtually nil). Actually, several psychedelic treatments for illnesses have been discovered by people underground. Dismissive and insulting remarks about paranoid, insane, psychotic, loser, deluded, schizophrenic, etc., hippies, only show the ignorance of the "poster(s)" about the true nature of psychedelic science, while making it also seem as though the "poster(s)" have hate-filled hearts, or at least no appreciation for anyone who uses psychedelics outside of a clinical research setting. Perhaps "they" just had really bad cluster headaches when they were ranting; in which case, it is my sincere hope that some ergine might start helping them ASAP. Sewell also penned the excellent article "So You Want to be a Psychedelic Researcher?", which may potentially help many others get their start in the field and advance the state of medicine. (That article was published both underground in The Entheogen Review and then later in the above-ground-research-focused MAPS Bulletin.) In addition, many--perhaps most--people who have been moved by their illegal psychedelic drug use end up being the very folks who FUND above ground research (although one of MAPS' largest long-time funders specifically required that none of his donations go toward any project that Halpern was involved with). I was, myself, instrumental in kick-starting the "autographed fine art prints as fundraiser" approach that MAPS has whole-heartedly embraced, resulting in many thousands of dollars going toward MAPS-sponsored research. To imply that I haven't done anything to advance research is simply untrue. To imply that anyone else who does not warm up to a particular snitch hasn't done anything to advance research is preposterous. "Shroomer" asks "Anonymous Loser", "Do you always go around insulting people?" and then ends with "Fucking prick". Readers can clearly figure out the score here.

Rick says, "John Halpern had the original idea to test BOL for cluster headaches, then worked with Torsten Passie to gather the initial experimental data. To their surprise, it worked and seems even more effective than LSD, in part because it can be given in larger doses than LSD since it's not psychedelic."

Halpern's "original idea" actually came from Andrew Sewell, who was inspired by the 1963 paper by renowned headache specialist Federigo Sicuteri, who treated patients suffering from migraine or cluster headache with BOL-148 (among other lysergic acid derivatives). Sicuteri found LSD to be more effective than BOL-148 for treating migraine, and he found methysergide to be more effective than LSD. Sicuteri's less-promising results using BOL-148 for treating migraine could explain Halpern and Passie's "surprise" that BOL-148 "seems even more effective than LSD" for treating cluster headaches; but, of course, migraines and cluster headaches are not the same.

Rick Doblin has accomplished some truly incredible work over the years in the field of psychedelic research, and I wholeheartedly support him on the following count: When he was asked by both government-sanctioned doctors doing above ground psychedelic research, as well as by members of the psychedelic underground, to NOT have John Halpern speak in person at the MAPS conference earlier this year (as Doblin had originally planned), he arranged for Halpern's talk to happen via video link instead. This is the exact sort of separation that it is clear that many people on both sides of the research fence feel more comfortable about. I am hopeful Halpern finds enough joy and satisfaction in his promising work with a non-psychedelic (structurally similar) chemical for headache treatment that he continues to stay physically away from such events. It was disheartening to hear that he made an appearance at the Horizons event organized by Neal M. Goldsmith more recently this year.

Halpern picked an unfortunate name for his corporation--one that is sure to raise the hackles of many who care deeply about entheogens. Perhaps this was strategic. Perhaps Halpern knew that this name would once again stir things up with those people who do not agree with snitchery. Maybe Halpern subscribes to the model that no publicity is bad publicity. Maybe he knows that people will now start linking to these comments, that search engines will again pony-up his name more readily... Alas, it isn't just the name of "Entheogen Corp" that is ironic; it is also sadly ironic that some people rot in prison for their work with LSD, while a snitch who goes free attempts to capitalize on a non-visionary spin-off of the drug. Albert Hofmann, always a psychedelic prisoners' advocate, is rolling over in his grave.

"John Halpern had the original idea to test BOL for cluster headaches, then worked with Torsten Passie to gather the initial experimental data."

The original idea to test BOL for cluster headache was actually mine. I wrote about it in Roberts and Winkelman's "Hallucinogens and Healing" book. Dr. Halpern went behind my back to work with Torsten Passie to conduct a clinical trial to test it. While I am pleased that the idea turned out to be a good one, let us give credit where credit is due.

I also wrote the original paper on LSD and psilocybin for cluster headache; Halpern was merely a second author. When I discovered his unfortunate relationship with the DEA, I was quite disgusted; I not only ceased the collaboration, but I left Harvard altogether to pursue cluster headache research at Yale.

Cluster headache is a terrible disease that is all but unimaginable to those who do not suffer from it. I am deeply committed to finding a cure. It is a shame that Halperngate is true, but if Dr. Halpern ends up doing something positive to help cluster headache sufferers, that would be great. Let us not confuse the two issues. Also let us not forget that BOL--which appears to be the first new medication for cluster headache in decades--is ultimately the result of activism by cluster headache patients themselves.

Thanks for the info, anonymous and Rick. I'm glad to hear this is more charitable than it initially sounded. The entheogencorp website isn't exactly doing them many favors. Hopefully BOL will be approved, and hopefully it will be made available cheaply, and then we'll know for sure.

I can see I used the word "informant" in error. ""Provided information to law enforcement" is more accurate.

Regardless of what you think of Halpern, it was not known that he had provided information to law enforcement until the Halperngate incident happened and was written about. It was a public service to get this information out. Calling the people who reported on it "Taliban" is bullshit. In the end, whatever people want to think about Halpern is up to them, but making important information available (and this was important information to the psychedelic community) is a good thing. Don't blame the whistle-blower.

John Halpern had the original idea to test BOL for cluster headaches, then worked with Torsten Passie to gather the initial experimental data. To their surprise, it worked and seems even more effective than LSD, in part because it can be given in larger doses than LSD since it's not psychedelic. Harvard and the University of Hannover subsequently obtained a use patient on BOL for cluster headaches, which is a totally appropriate step to take to raise funds to bring BOL to market as a prescription medicine. John and Torsten then created a for-profit company and are working to raise funds for BOL research. This is all to the good and provides evidence of the value of renewed research with psychedelics, which led to the discovery of the therapeutic potential of BOL.

Regarding criticism of John himself, I was mentioned as a reference in the prior post by "someone" and feel compelled to comment. When someone is accused of being an informant, that is understood to mean that the informant was working secretly to provide information that led to an arrest. John was not an informant. The informant was Todd Skinner, who was working undercover as Leonard's partner and was providing information that led to the arrest. As the record shows, John was first questioned by the police after Todd's information led to the arrest. Under threat of jail, John cooperated with the police, with that cooperation limited entirely to matters relating to Leonard. Furthermore, John was not the only person to cooperate with the police after the arrest. Rightly so, the psychedelic code of honor is absolutely against cooperation with the police by providing information against others for matters that should not even be crimes in the first place. John and others did so and violated this code of honor. Others not in that same situation cannot know exactly what those pressures feel like so some compassion is in order for people who have been in these horrible situations. Since then, John has made major contributions to psychedelic research and to the psychedelic community. His life, and indeed all of ours, should be judged by the totality of what we do.

John's work on BOL has the chance of dramatically helping thousands of people with cluster headaches for whom the pharmaceutical industry has little to offer. While BOL for cluster headaches is not psychedelic psychotherapy (which is what MAPS is most interested in exploring), the approval of BOL would still be step forward both for patients, for psychedelic activists, for the psychedelic community.

One other thing. A few posts have lamented Halprin (or anyone) profiting.

This drug is not patented (or patentable), which is why he couldn't interest big Pharma.

It is very unlikely that this will be any kind of bib money-maker. It is entirely possible that this should be viewed as charitable work.

I agree with jamesk. The Entheogen Corporation. Wow. PKD would be proud

First of all, I do feel empathy and compassion for cluster-headache sufferers (even ones with seeming personality disorders), and as I already said, I do support the development of any medicines that can help.

Let's get to the real question: Were the main charges of "Halperngate" - that John Halpern was a DEA informant true, or false? Answer: True. There is abundant documentation of this, but even if there wasn't, Rick Doblin almost immediately admitted that this was true. Since Doblin and MAPS supported this work and made it possible, he'd be in a pretty good situation to know, and since he continues to support Halpern (had him on a videolink at the last MAPS conference) you're not going to tell me he's a Taliban or slanderer are you? He's chosen to continue to work with Halpern DESPITE Halpen being an informant. That is his choice, but at least he's not slandering the members of the community who brought the information on Halpern to light.

You call the former editor of the ER a Taliban. Now, my understanding of the Taliban is that they are deeply intolerant of personal freedom. The only thing that the Halperngate article was intolerant of was being a fucking snitch to the DEA and getting your friends arrested. So, since you characterize that attitude as Taliban-ish I guess that means you are in favor of snitching. Great. You sound like someone who has taken an entheogen or two yourself, probably not only from Halpern's approved sources either, so don't you think it is morally hypocritical to buy illicit drugs and then condemn others for making and distributing them?

You say the "Halpern-haters" done nothing to advance research. Well, the former editor of ER also edited a bunch of special issues of MAPS Bulletin. MAPS is the main organization promoting research using psychedelics. So how could these two facts be squared away? They can't. Are you also going to tell me that Erowid does nothing to advance research on psychedelics? Because that's who the former editor works with now. You are slandering him for no valid reason, simply because he made public the information on Halpern's record as a DEA informant. Anybody who knows the people who wrote the Halperngate and other associated articles knows they are the furthest possibly thing from Taliban. They just resent the presence of known DEA informants within their community, and I agree with them.

The fact is, pretty much everybody involved in this community wants psychedelics legalized for medicinal use, and otherwise. There are variations in people's comfort level with informants who help get their friends sent to jail. If Halpern really wants to change the negative perceptions of him out there, he doesn't need to get his patients to attack those who "outed" him. He just needs to tell the truth about what happened and why.

You are the one with the misplaced anger. I'm not ranting and raving at Halpern at public forums. I'm just saying, I don't think it is fair or appropriate for him to form a corporation marketing BOL given that others have done a lot of research on this before him, and especially given his background as an informant. Were he to make it a non-profit and give away the proceeds to fund MAPS or other psychedelic research studies, he would merit more respect.

"bullshit cluster headaches", is cancer bullshit? Is AIDS bullshit? Do you always go around insulting people? There's over a million of us living with this crap, and this is the first real hope we've ever had.

"All about money", do you live in some altruistic fantasy land where medications are approved for human consumption and then given away for free?

Fucking prick.

yea notice everyone that "someone" (aka probably the loser who wrote that attack piece against Halpern) states it like it is:

no one involved in writing that paranoid piece was a journalist. People in jail? A guy who edits a non-mainstream magazine about how to get high? A schizophrenic who campaigned against unjust sentences?

And they are so obsessed about Halpern that they keep this attack up (and keep a stupid article up on the net in deluded self-importance) for years! You people are absolutely, as one poster so aptly put it, "the TALIBAN wing of the psychedelic scene", representing the drug dealer types who want to keep these psychedelics illegal so they can make more money. And that is the real smell test.

Have any of these Halpern-haters ever done a single thing to advance research that may lead to an important medicine? No. Because they are hippy self-appointed nobodies who have nothing better to do with their lives than run their mouths and carry on the same misinformed rant for almost a decade. Get over it already. At least Halpern is making a positive contribution to advancing legitimate medicine that will actually benefit people.

As someone who has suffered chronic cluster headaches for almost 20-years he has my full support, and the support of our community. Too bad you aren't a clusterhead yourself; you might find an ounce of humanity and spare us your pitiful and misplaced anger.

I just read it. definitely funny and accurate description! That amateur hour fake journalism is so Taliban. Probably that sour taste in your mouth is leftover DMT you don't know how to get down your lungs.

"Cash in on this"? huh? Ah, how does a drug get developed then? People like you just don't see it do you? You only see what you believe and are a creature of fear that obviously thinks dumb attacks from what a decade ago (?) is more important than treatment of cluster headache. So yea. You don't get it. None of those people who wrote that attack stuff have any credibility as journalists and it shows dude. I think that unjust sentencing guy was psychotic. Wow "Editor of the entheogen review": T A L I B A N.

I love it. Count me in. Wacko Taliban bullshit artists who appoint themselves top leaders against all infidels! Long live the Underground that wants to keep this stuff illegal and can't even begin to see a good thing when it comes. Any sane person should see through that psycho stalker halperngate attack. But if you want to defend it: it is okay to live your life paranoid and fear-filled. What a non story. Cluster headache, lsd, psilocybin, this BOL stuff: THAT is a STORY.

Taliban wing of the Psychedelic underground? Are you fucking nuts? Then editor of the Entheogen review, founder of the Committee Against Unjust Sentencing, prisoners in jail because of snitches - these are the people who wrote up the Halperngate and Halperngate 2 articles. He may be a good scientist, and of course any medicines for cluster headaches are useful and good, but his attempt to cash in on this, given his history of being, yes, a DEA informant (this is documented, not conjecture) leaves a sour taste.

Halperngate... yea, there is "high" journalism for you. Total slanted piece of crap written by the Taliban-wing of the Psychedelic underground. And none of it is relevant to what IS important: treating cluster headache. At least Halpern actually is doing something positive. Nice to see there are always people with nothing better to do than try to tear down something good.

"Halperngate" is easily Googled

that is because Halpern WAS NEVER a dea snitch. Despite the horrible, lie filled bs pumped out by the paranoid wing - he's stuck it out and thank God he has. I have hope that my cluster headaches will never be visited upon another person during their lifetime like it has in mine. BOL is not hallucinogenic at any dose (I took time to read all the publications carefully).

The guys who paid the highest personal price for this research are the inventors and the docs who started this company. I hope they get BOL to market ASAP!

no one seems to remember the flap about Halpern being a DEA snitch

From what I've read it seems they wouldn't neccessarily have to double-blind LSD effects because doses effective for breaking a cluster headache cycle are sub-psychedelic. But maybe I'm wrong.
I knew it sounded too beautiful to be true: take 1 pill to get rid of that horrible headache, take 3 pills to trip out...
Anyway maybe it will bring some good to psychonauts as well. Like: maybe BOL-148 will make a good precursor?... ;)

i was under the impression that hoffman stumbled on lsd, he was investigating ergot derivatives because ergotamine was being used as a treatment for migraines. to that end, i've often thought he was massively successful.

Well, I'm disappointed that it is a for-profit. Personally I just think a Harvard Medical School salary is sufficient. Why not kick whatever money can be made back into research? Wouldn't that be a better way to repay the countless other researchers (academic and otherwise) whose findings have made this possible, and who not only were never renumerated, but sometimes paid a high personal price themselves? I mean, if someone is going to make a mint off this, why Halpern, or Halpern and Passie?

cluster headaches suck, not troubled by the fact that treatment is progressing.

alternate definitions can be useful:
q: "you heard of entheogens?"
a: "yeah, don't they make tylenol?"

Yo... go check out their website: www.entheogencorp.com. Looks like a different sort of ambition than typical. How exactly will this company "corner the market on the hallucinogen-cluster headache medicine market" when there is no such legitimate market and when BOL is NOT a hallucinogen? Meanwhile, no one before Halpern and crew got off their asses to do any of this. Hat's off to them! I hope it helps cluster headache patients and soon!

The name "Entheogen Corporation" is a crazy science fiction paradox concept worthy of satire. However, trying to market "non hallucinogenic hallucinogens" (wrap your head around that one) for commercial application is inevitable. Some one has to go first.

So, is anybody else troubled by the fact that Halpern has created a for-profit company called "Entheogen Corporation" (is Entheogen going to be trademarked?), which holds the global patent on a molecule developed by researchers before he was even born, and is trying to corner the market on the hallucinogen-cluster headache medicine market?