I was recently contacted by a curious person who was interested in using choline or acetylcholine promoters to enhance the memory of psychedelic or dissociative session. It is true that while in a waking state acetlycholine is essential in both memory storage and recall, but in a dreaming or hallucinogenic state acetylcholine only promotes memory recall and compression (associative memory linking), and during this process new memory formation is essentially offline. I guessed that if anything, the addition of acetylcholine promoters would probably enhance the visuals of the psychedelic trip (which mimics a waking dream), but would do little to improve memory of the experience.
Undaunted, underground researchers went to work on this problem by combining typical doses of both Ketamine and LSD with pre-doses of 800mg of galantamine and 500mg choline, both acetylcholine precoursers and promoters. The report has come back that the addition of acetylcholine promoters made the visuals extremely intense, impossible to stop, and impossible to steer in a conscious direction. "Full-blown eyelid movie," was a telling snippet, and the fact that the images were not always pleasant and were impossible to control is another telling fact. And this is from someone who has tried both substances in combo before with very predictable results. The addition of acetylcholine promoters made the internal imaging engine go into an unstoppable overdrive.
I could spend some time discussing Hobson's AIM model of 5-HT and acetylcholine modulators ruling the balance between waking/external perception and dreaming/internal imagination, but you probably know all that stuff already. If not, Google
The Dream Drugstore for a full read of the topic. If anyone else has info on this combo, pass it on please.
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