Research into LSD is not confined to medicine. Franz Vollenweider, of the Heffter Research Institute in Zurich, for example, is scanning people’s brains to try to understand how hallucinogenic drugs cause changes in consciousness.
And biotechnology may lead to a new generation of hallucinogenic drugs. Edwin Wintermute and his colleagues at Harvard have engineered yeast cells to carry out two of six steps in the pathway needed to make lysergic acid, the precursor of LSD. They hope to add the other four shortly. Once the pathway has been created, it can be tweaked. That might result in LSD-like drugs that are better than the original.
Even if that does not happen, making lysergic acid in yeast is still a good idea. The chemical is used as the starting point for other drugs, including nicergoline, a treatment for senile dementia. The current process for manufacturing it is a rather messy one involving ergot, a parasite of rye.
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